warfarin induced massive and bilateral skin necrosis of the breasts: a case report and review of the literatures

warfarin induced skin necrosis is a rare complication associated with the use of oral ‎anticoagulants. most patients develop this complication at the initiation of therapy. the complication is ‎usually associated with an underlying thrombophilia. here we describe a case of a 75 year old ‎patient who developed skin necrosis in her both breasts during warfarin treatment for a ‎deep vein thrombosis. thrombophilia screening demonstrated the presence of protein s and ‎antithrombin iii deficiency. the necrotic lesion was excised and defects eventually ‎covered with skin flaps.